Oleamide: The Hypnotic Actions of the Fatty Acid
Oleamide is a natural compound of oleic acid, an unsaturated omega-9 fatty acid found naturally in the body and in many fats, and ammonia. Oleamide is produced in the human brain and also in the brain of most mammals.
Oleamide can be used to promote calm and relaxation, to reduce stress, and to promote healthy sleep by reducing sleep time. At almost all doses, sleep reduces latency (the time taken to fall asleep). Oleamide is also known to increase serotonin signaling in the brain. Serotonin is an important neurotransmitter that is crucial for maintaining mood. Increased serotonin levels are often associated with an improvement in mood.
As a dietary supplement it is fairly new, first isolated in 1989. Studies have shown that it accumulates in the central nervous system (CNS) before sleep, where it provides relaxing and soothing effects. It is naturally broken down by an enzyme called FAAH. Interestingly, this enzyme is also responsible for the degradation of anandamide (or AEA) – a neurotransmitter with multiple functions in the human body, including promoting rest and relaxation.
Concentrations of Oleamid have been shown to increase in the brain and spinal fluid 4-6 times after only a few hours without normal sleep.
At larger doses, this dietary supplement has been shown to contribute to restful sleep. At almost all doses, sleep reduces latency (the time taken to fall asleep)
In terms of its mechanisms of action, this supplement is associated with an increase in GABA signaling (the GABA system is known to cause sedative effects on the body). Oleamide does not specifically bind to GABA receptors, but rather acts as an effective component to enhance GABA signaling.
Oleamide is also known to increase serotonin signaling in the brain. Serotonin is an important neurotransmitter that is crucial for maintaining mood. Increased serotonin levels are often associated with an improvement in mood. In fact, Oleamide is remarkably effective in increasing serotonin signaling even at very low doses.
This exciting dietary supplement is a fatty acid compound produced in the human brain from ammonia and oleic acid (found in olive oil). It is structurally and functionally similar to anandamide and several other fatty acids. Its natural function in the brain is to help sleep, and it has been found to accumulate up to 6 times after just a few hours of sleep deprivation. When taken as a dietary supplement, it can be used to promote calm and relaxation, to reduce stress and to promote healthy sleep by reducing sleep time.
Other benefits of this supplement include powerful anti-inflammatory effects in the brain and the ability to function as a powerful neuroprotector – protecting the brain from toxins and stress.
Oleamide has been shown to be effective against pain at higher doses. The recommended daily dose is 40-300 mg, divided into one to three times daily. Do not exceed the recommended daily dose. Talk to your physician if you have any medical conditions that you are being treated for.
The side effects of this supplement have not been fully investigated and more human studies are required. The recommended dose on this site is safe, according to many users and research results. Since this supplement is a naturally occurring compound, produced by the brain to contribute to sleep, it is highly unlikely that adverse effects would occur. The body has a highly developed system for preventing excess natural products and can easily convert / break down this supplement if needed. It is possible that some people may experience allergies, in which case you should immediately stop using this dietary supplement.
Oleamide can slow down motor skills, even at medium doses. It’s not advised to drive or use heavy machinery when taking this supplement. There are not enough studies for this supplement for pregnant and lactating women, therefore this supplement is not recommended for pregnant and lactating women. Do not use this supplement without first consulting your doctor if you have any medical conditions or are taking any medicine.